aP2
Adipocyte Protein 2
Table of Contents
I. Introduction
II. Structure
III. Function
IV. Medical Relevance
A. Asthma
B. Diabetes
C. Fatty liver disease
D. Heart Disease
E. Obesity
V. Conclusion
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Crystalline Structure of murine aP2 1
I. Introduction
aP2 is a highly functional carrier protein associated with fatty acids. aP2 stands for adipocyte protein 2 (the 2 signifies that there is another adipocyte protein. aP1 is commonly associated with psoriasis). 2
An adipocyte is a cell that specializes in the storage of fat and is commonly found in connective tissues. 3
The protein is formally classified as a fatty acid binding protein and is also commonly called FABP4. These are a family of 17 proteins responsible for attaching to fatty acids 4 and carrying (hence the name carrier protein) them between cell organelles and cellular membranes. 4
II. Structure
aP2 is a crystalline structure protein Studies on the structure both murine (mouse) and human
Crystalline Structure of human aP2 with a bound palmitic acid
shown in cyan. 5
Footnotes/References
1 Xu Z, Bernlohr DA, Banaszak LJ. Crystal structure of recombinant murine adipocyte lipid-binding protein. Biochemistry: v31, p.3484-3492. 1992 Apr 7.
http://www.ncbi.nlm.nih.gov/pubmed/1554730
2 http://en.wikipedia.org/wiki/Adipocyte_protein_2
3 New Oxford American Dictionary
4 http://en.wikipedia.org/wiki/Fatty_acid-binding_protein
5 Eric Marr, Mark Tardie, Maynard Carty, Tracy Brown Phillips, Ing-Kae Wang, Walt Soeller, Xiayang Qiu, and George Karam. Expression, purification, crystallization and structure of human adipocyte lipid-binding protein (aP2). Acta Crystallogr Sect F Struct Biol Cryst Commun. 62(Pt 11): 1058–1060. Published online 2006 October 25.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17077479#supplementary-material-sec
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