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Exam I Materials

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Saved by Christopher Korey
on January 12, 2009 at 12:44:00 pm
 

 

The first section of the course focuses on the chemistry of DNA, the interaction of DNA with proteins, and the mechanisms by which the genetic material is copied.  The readings for each section are outlined below with links to the specific web pages.  There is also a link to the online review page for this exam, practice exam problems and their answers.

 

Exam I Review Page

 

Exam I Practice Problems

Exam I Practice Problem Answers

 


Lecture 1: The Central Dogma

 

Lecture 2: DNA Structure and Chemistry

 

Readings:

Molecular Cell Biology: DNA Structure

 

Lecture 3: Protein-DNA Interactions

 

Lecture 4: DNA Topology and Nucleosomes

 

Readings:

Biochemistry: Topology

Molecular Cell Biology: Topoisomerase I and II Mechanisms

 

Two animations which demonstrate how DNA is wrapped around nucleosomes with the cell's nucleus.  Only the beginning of the second movie is relevant to our discussion of nucleosomes.

 

     

 

Lecture 5: DNA Replication I (The Replication Fork)

 

Readings:

 

Animations and Movies:

 

DNAtube: Helicase Animation

 

Animation of the Basic Replication Mechanism

 

The following two movies provide two different perspectives on the repliation process.  The first movie is a cartoon animation that reviews all of the important proteins and their functions during the replication of the leading and lagging strands.  The second movie uses the three dimensional crystal structures of all the proteins to recreate a more true to life real-time view of the replication fork.

 

     

 

Lecture 6: DNA Replication II (Origins and Telomeres)

 

 

 

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